Open Access Repository
Factors contributing to sex differences in functional outcomes and participation after stroke




Full text not available from this repository.
Abstract
Objective: To examine factors contributing to the sex differences in functional outcomes and participation restriction after stroke.Methods: Individual participant data on long-term functional outcome or participation restriction (i.e., handicap) were obtained from 11 stroke incidence studies (1993-2014). Multivariable log-binomial regression was used to estimate the female:male relative risk (RR) of poor functional outcome (modified Rankin Scale score >2 or Barthel Index score Results: In unadjusted analyses, women experienced worse functional outcomes after stroke than men (1 year: pooled RRunadjusted 1.32, 95% confidence interval [CI] 1.18-1.48; 5 years: RRunadjusted 1.31, 95% CI 1.16-1.47). However, this difference was greatly attenuated after adjustment for age, prestroke dependency, and stroke severity (1 year: RRadjusted 1.08, 95% CI 0.97-1.20; 5 years: RRadjusted 1.05, 95% CI 0.94-1.18). Women also had greater participation restriction than men (pooled MDunadjusted -5.55, 95% CI -8.47 to -2.63), but this difference was again attenuated after adjustment for the aforementioned factors (MDadjusted -2.48, 95% CI -4.99 to 0.03).Conclusions: Worse outcomes after stroke among women were explained mostly by age, stroke severity, and prestroke dependency, suggesting these potential targets to improve the outcomes after stroke in women.
Item Type: | Article |
---|---|
Authors/Creators: | Phan, HT and Blizzard, CL and Reeves, MJ and Thrift, AG and Cadilhac, DAC and Sturm, J and Heeley, E and Otahal, P and Vemmos, K and Anderson, C and Parmar, P and Krishnamurthi, R and Barker-Collo, S and Feigin, V and Bejot, Y and Cabral, NL and Carolei, A and Sacco, S and Chausson, N and Olindo, S and Rothwell, P and Silva, C and Correia, M and Magalhaes, R and Appelros, P and Korv, J and Vibo, R and Minelli, C and Gall, SL |
Keywords: | stroke, functional outcome, sex difference |
Journal or Publication Title: | Neurology |
Publisher: | Lippincott Williams & Wilkins |
ISSN: | 0028-3878 |
DOI / ID Number: | 10.1212/WNL.0000000000005602 |
Copyright Information: | Copyright © 2018 American Academy of Neurology |
Related URLs: | |
Item Statistics: | View statistics for this item |
Actions (login required)
![]() |
Item Control Page |