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Hypothalamic demyelination causing panhypopituitarism

Dixon-Douglas, J, Burgess, J ORCID: 0000-0003-4748-9571 and Dreyer, M 2018 , 'Hypothalamic demyelination causing panhypopituitarism' , Internal Medicine Journal, vol. 48, no. 5 , pp. 580-582 , doi: 10.1111/imj.13787.

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Hypothalamic involvement in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is rare and endocrinopathies involving the hypothalamic-pituitary axis in patients with demyelinating conditions have rarely been reported. We present two cases of MS/NMOSD with associated hypothalamic-pituitary involvement and subsequent hypopituitarism, including the first report of a patient with hypothalamic demyelination causing panhypopituitarism. Differential diagnoses, including alemtuzumab-related and primary pituitary pathology are discussed.

Item Type: Article
Authors/Creators:Dixon-Douglas, J and Burgess, J and Dreyer, M
Keywords: demyelinating disease; hypopituitarism; hypothalamus; multiple sclerosis; neuromyelitis optica
Journal or Publication Title: Internal Medicine Journal
Publisher: Blackwell Publishing Asia
ISSN: 1444-0903
DOI / ID Number: 10.1111/imj.13787
Copyright Information:

© 2018 Royal Australasian College of Physicians

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