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Abstract

Hypothalamic involvement in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) is rare and endocrinopathies involving the hypothalamic-pituitary axis in patients with demyelinating conditions have rarely been reported. We present two cases of MS/NMOSD with associated hypothalamic-pituitary involvement and subsequent hypopituitarism, including the first report of a patient with hypothalamic demyelination causing panhypopituitarism. Differential diagnoses, including alemtuzumab-related and primary pituitary pathology are discussed.

Item Type:	Article
Authors/Creators:	Dixon-Douglas, J and Burgess, J and Dreyer, M
Keywords:	demyelinating disease; hypopituitarism; hypothalamus; multiple sclerosis; neuromyelitis optica
Journal or Publication Title:	Internal Medicine Journal
Publisher:	Blackwell Publishing Asia
ISSN:	1444-0903
DOI / ID Number:	10.1111/imj.13787
Copyright Information:	© 2018 Royal Australasian College of Physicians
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