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Abstract

The treatment of Mycobacterium tuberculosis infection is often viewed in isolation from other human microbialsymbionts. Understandably, the clinical priority is eliminating active or latent tuberculosis (TB) in patients. Withthe increasing resolution of molecular biology technologies, it is becoming apparent that antibiotic treatmentcan perturb the homeostasis of the host microbiome. For example, dysbiosis of the gut microbiota has beenassociated with an increased risk of the development of asthma, obesity and diabetes. Therefore, fundamentalquestions include: Does TB chemotherapy cause disruption of the human microbiome and adverse effects inpatients; and are there signature taxa of dysbiosis following TB treatment. In this review, we examine recentresearch on the detection of changes in the microbiome during antibiotic administration and discuss specificfindings that relate to the impact of anti-tubercular chemotherapy.

Item Type:	Article
Authors/Creators:	O'Toole, R and Gautam, SS
Keywords:	Mycobacterium tuberculosis; microbiome; antibiotic
Journal or Publication Title:	Tuberculosis
Publisher:	Churchill Livingstone
ISSN:	1472-9792
DOI / ID Number:	10.1016/j.tube.2018.08.015
Copyright Information:	© 2018 Elsevier Ltd
Related URLs:	Google Scholar: O'Toole, R UTAS Profile: O'Toole, R
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