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Abstract

Introduction: Our previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inherent in study-level data means that the results are not definitive and cannot provide an accurate assessment of the size of any effect. Therefore, we propose to undertake an individual patient data (IPD) meta-analysis to determine whether the effect of vitamin D supplementation on bone density in children differs according to baseline vitamin D status, and to specifically estimate the effect of vitamin D in children who are vitamin D deficient.Methods and Analysis: This study has been designed to adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses of IPD statement. We will include randomised placebo-controlled trials of vitamin D supplementation reporting bone density outcomes at least 6 months after the study commenced in children and adolescents (aged

Item Type:	Article
Authors/Creators:	Winzenberg, T and Lamberg-Allardt, C and Fuleihan, GE-H and Molgaard, C and Zhu, K and Wu, F and Riley, RD
Keywords:	paediatric endocrinology, preventive medicine, rheumatology
Journal or Publication Title:	BMJ Open
Publisher:	BMJ Group
ISSN:	2044-6055
DOI / ID Number:	10.1136/bmjopen-2017-019584
Copyright Information:	© 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Related URLs:	Google Scholar: Winzenberg, T UTAS Profile: Winzenberg, T Google Scholar: Wu, F
Item Statistics:	View statistics for this item

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