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Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study

He, Y, Tian, J ORCID: 0000-0001-7746-7782, Oddy, WH ORCID: 0000-0002-6119-7017, Dwyer, T and Venn, AJ ORCID: 0000-0001-7090-1398 2018 , 'Association of childhood obesity with female infertility in adulthood: a 25-year follow-up study' , Fertility and Sterility, vol. 110, no. 4 , 596-604.e1 , doi: 10.1016/j.fertnstert.2018.05.011.

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Abstract

Objective: To evaluate whether childhood obesity is associated with infertility in women's reproductive-aged life.Design: Prospective longitudinal study.Setting: Not applicable.Intervention(s): None.Patient(s): A total of 1,544 girls, aged 7-15 years in 1985, and who completed questionnaires at follow-up in 2004-2006 and/or 2009-2011.Main outcome measure(s): Infertility was defined as having difficulty conceiving (had tried for ≥12 months to become pregnant without succeeding) or having seen a doctor because of trouble becoming pregnant.Result(s): At ages from 7-11 years, girls at both the lower and upper end of the body mass index (BMI) z score had increased risk of infertility. Compared with normal weight girls, those with obesity at ages 7-11 years were more likely in adulthood to report infertility (adjusted relative risk [aRR] = 2.94, 95% confidence interval [CI] 1.48-5.84), difficulty conceiving (aRR = 3.89, 95% CI 1.95-7.77), or having seen a doctor because of trouble becoming pregnant (aRR = 3.65, 95% CI 1.90-7.02) after adjusting for childhood age, follow-up length, highest parental education, and marital status.Conclusion(s): Childhood obesity before 12 years of age appears to increase the risk of female infertility in later life.

Item Type: Article
Authors/Creators:He, Y and Tian, J and Oddy, WH and Dwyer, T and Venn, AJ
Keywords: childhood, body composition, body mass index, infertility, waist-to-height ratio
Journal or Publication Title: Fertility and Sterility
Publisher: Elsevier Science Inc
ISSN: 0015-0282
DOI / ID Number: 10.1016/j.fertnstert.2018.05.011
Copyright Information:

Copyright 2018 American Society for Reproductive Medicine

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