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Capstone laboratory experiment investigating key features of palladium-catalyzed Suzuki−Miyaura cross-coupling reactions


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Abstract
This two-part laboratory experiment is concerned with investigating key aspects of the Suzuki-Miyaura cross-coupling reaction. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are presented in the classroom. In contrast, the second part employs guided-inquiry learning strategies to challenge students to design, set up, and perform a preparative-scale Suzuki-Miyaura reaction and suggest workup and isolation protocols. By design, this experiment, which represents one of the final experiments performed in the third-year undergraduate chemistry laboratory program, serves as a capstone learning experience for students.
Item Type: | Article |
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Authors/Creators: | Pullen, R and Olding, A and SMith, JA and Bissember, AC |
Keywords: | laboratory instruction. inquiry-based/discovery learning, catalysis |
Journal or Publication Title: | Journal of Chemical Education |
Publisher: | Amer Chemical Soc |
ISSN: | 0021-9584 |
DOI / ID Number: | https://doi.org/10.1021/acs.jchemed.7b00964 |
Copyright Information: | Copyright 2018 American Chemical Society and Division of Chemical Education, Inc. |
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