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Abstract

Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system(CNS) that can rapidly respond to changes within their environment by modulatingtheir proliferation, motility and differentiation. OPCs differentiate into myelinatingoligodendrocytes throughout life, and both cell types have been implicated in maintainingand modulating neuronal function to affect motor performance, cognition and emotionalstate. However, questions remain about the mechanisms employed by OPCs andoligodendrocytes to regulate circuit function, including whether OPCs can only influencecircuits through their generation of new oligodendrocytes, or can play other regulatoryroles within the CNS. In this review, we detail the molecular and cellular mechanisms thatallow OPCs, newborn oligodendrocytes and pre-existing oligodendrocytes to regulatecircuit function and ultimately influence behavioral outcomes.

Item Type:	Article
Authors/Creators:	Pepper, RE and Pitman, KA and Cullen, CL and Young, KM
Keywords:	NG2 glia, myelin, oligodendrocyte, anxiety, motor function, depression, learning, neuronal activity
Journal or Publication Title:	Frontiers in Cellular Neuroscience
Publisher:	Frontiers Research Foundation
ISSN:	1662-5102
DOI / ID Number:	10.3389/fncel.2018.00399
Copyright Information:	Copyright 2018 Pepper, Pitman, Cullen and Young. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Related URLs:	Google Scholar: Pitman, KA Google Scholar: Cullen, CL UTAS Profile: Cullen, CL UTAS Profile: Young, KM
Item Statistics:	View statistics for this item

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