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Changes in biomarkers of cardiac dysfunction during exacerbations of chronic obstructive pulmonary disease

Shafuddin, E, Chang, CL, Cooray, M, Tuffery, CM, Hopping, SJ, Sullivan, GD, Jacobson, GA ORCID: 0000-0002-3409-8769 and Hancox, RJ 2018 , 'Changes in biomarkers of cardiac dysfunction during exacerbations of chronic obstructive pulmonary disease' , Respiratory Medicine, vol. 145 , pp. 192-199 , doi: 10.1016/j.rmed.2018.11.008.

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Background:Cardiac dysfunction is associated with a higher mortality in exacerbations of chronic obstructive pulmonary disease (COPD). It is unknown how the heart responds to treatment of COPD exacerbations. We followed cardiac biomarker levels during hospital admissions for exacerbations of COPD and hypothesised that these biochemical markers of cardiac dysfunction might be affected the severity and treatment of exacerbations of COPD.Methods:N-terminal pro-B-type natriuretic peptide (NT-proBNP) and troponin T were measured at admission, 12 h, 72 h, and clinical stability in 176 patients. In a second cohort (n = 93), associations between blood salbutamol concentrations and biomarker changes at 12 h were analysed.Results:NT-proBNP increased from a geometric mean of 43 pmol/L at admission to 56 pmol/L at 12 h (p Conclusions:NT-proBNP continues to rise after admission to hospital for COPD exacerbations and a minority of patients have clinically significant rises in cardiac troponins. These rises were associated with nebulised beta2-agonist treatment. These findings suggest that high doses of beta2-agonists may exacerbate cardiac dysfunction in COPD.

Item Type: Article
Authors/Creators:Shafuddin, E and Chang, CL and Cooray, M and Tuffery, CM and Hopping, SJ and Sullivan, GD and Jacobson, GA and Hancox, RJ
Keywords: COPD, beta2-agonist, cardiac dysfunction, chronic obstructive pulmonary disease, natriuretic peptide, troponin
Journal or Publication Title: Respiratory Medicine
Publisher: W B Saunders Co Ltd
ISSN: 0954-6111
DOI / ID Number: 10.1016/j.rmed.2018.11.008
Copyright Information:

Copyright 2018 Elsevier Ltd.

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