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Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology

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Chong, WC, Shastri, MD ORCID: 0000-0002-1012-2779 and Eri, R ORCID: 0000-0003-1688-8043 2017 , 'Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology' , International Journal of Molecular Sciences, vol. 18, no. 4 , pp. 1-19 , doi: 10.3390/ijms18040771.

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Abstract

The endoplasmic reticulum (ER) is a complex protein folding and trafficking organelle. Alteration and discrepancy in the endoplasmic reticulum environment can affect the protein folding process and hence, can result in the production of misfolded proteins. The accumulation of misfolded proteins causes cellular damage and elicits endoplasmic reticulum stress. Under such stress conditions, cells exhibit reduced functional synthesis, and will undergo apoptosis if the stress is prolonged. To resolve the ER stress, cells trigger an intrinsic mechanism called an unfolded protein response (UPR). UPR is an adaptive signaling process that triggers multiple pathways through the endoplasmic reticulum transmembrane transducers, to reduce and remove misfolded proteins and improve the protein folding mechanism, in order to improve and maintain endoplasmic reticulum homeostasis. An increasing number of studies support the view that oxidative stress has a strong connection with ER stress. During the protein folding process, reactive oxygen species are produced as by-products, leading to impaired reduction-oxidation (redox) balance conferring oxidative stress. As the protein folding process is dependent on redox homeostasis, the oxidative stress can disrupt the protein folding mechanism and enhance the production of misfolded proteins, causing further ER stress. It is proposed that endoplasmic reticulum stress and oxidative stress together play significant roles in the pathophysiology of bowel diseases.

Item Type: Article
Authors/Creators:Chong, WC and Shastri, MD and Eri, R
Keywords: gastrointestinal, ER stress, colitis, endoplasmic reticulum stress, unfolded protein response, oxidative stress, antioxidant mechanisms, misfolded protein, inflammatory bowel disease
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: MDPI
ISSN: 1661-6596
DOI / ID Number: 10.3390/ijms18040771
Copyright Information:

© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Additional Information:

Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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