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MRI-detected osteophytes of the knee: natural history and structural correlates of change

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Zhu, Z ORCID: 0000-0003-3913-2564, Ding, C ORCID: 0000-0002-9479-730X, Han, W ORCID: 0000-0003-1590-7433, Zheng, S ORCID: 0000-0003-3552-1247, Winzenberg, T ORCID: 0000-0002-4112-3491, Cicuttini, F and Jones, G ORCID: 0000-0002-9814-0006 2018 , 'MRI-detected osteophytes of the knee: natural history and structural correlates of change' , Arthritis Research & Therapy, vol. 20, no. 1 , pp. 1-11 , doi: 10.1186/s13075-018-1734-5.

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Abstract

Background: The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-detected OP change over time. Thus, the aim of current study is to describe the natural history of knee MRI-detected OP, and to determine if knee structural abnormalities are associated with change of MRI-detected OP in a longitudinal study of older adults.Methods: Randomly selected older adults (n = 837, mean age 63 years) had MRI at baseline and 413 of them had MRI 2.6 years later to measure MRI-detected OP, cartilage defects, cartilage volume, bone marrow lesions (BMLs), meniscal extrusion, infrapatellar fat pad (IPFP) quality score/maximum area and effusion-synovitis.Results: Over 2.6 years, average MRI-detected OP score increased significantly in all compartments. The total MRI-detected OP score remained stable in 53% of participants, worsened (≥ 1-point increase) in 46% and decreased in 1%. Baseline cartilage defects (RR, 1.25-1.35), BMLs (RR, 1.16-1.17), meniscal extrusion (RR, 1.22-1.33) and IPFP quality score (RR, 1.08-1.20) site-specifically and independently predicted an increase in MRI-detected OP (p values all ≤ 0.05), after adjustment for covariates. Presence of IPFP abnormality was significantly associated with increased MRI-detected OPs but became non-significant after adjustment for other structural abnormalities. Total (RR, 1.27) and suprapatellar pouch effusion-synovitis (RR, 1.22) were both associated with increased MRI-detected OPs in the lateral compartment only (both p Conclusion: Knee MRI-detected OPs are common in older adults and are likely to progress. The association between baseline structural abnormalities and worsening MRI-detected OPs suggest MRI-detected OP could be a consequence of multiple knee structural abnormalities.

Item Type: Article
Authors/Creators:Zhu, Z and Ding, C and Han, W and Zheng, S and Winzenberg, T and Cicuttini, F and Jones, G
Keywords: Osteoarthritis, magnetic resonance imaging, steophyte, natural history
Journal or Publication Title: Arthritis Research & Therapy
Publisher: Biomed Central Ltd
ISSN: 1478-6362
DOI / ID Number: 10.1186/s13075-018-1734-5
Copyright Information:

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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