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The link between regional tidal stretch and lung injury during mechanical ventilation

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Yen, S ORCID: 0000-0001-6208-3313, Preissner, M, Bennett, E ORCID: 0000-0002-9818-827X, Dubsky, S, Carnibella, R, O'Toole, R ORCID: 0000-0002-4579-4479, Roddam, L ORCID: 0000-0002-4152-0681, Jones, H, Dargaville, PA, Fouras, A and Zosky, GR ORCID: 0000-0001-9039-0302 2018 , 'The link between regional tidal stretch and lung injury during mechanical ventilation' , American Journal of Respiratory Cell and Molecular Biology , pp. 1-35 , doi: 10.1165/rcmb.2018-0143OC.

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Abstract

Aim: This study aimed to assess the association between regional tidal volume (VT), regional functional residual capacity (FRC) and the expression of genes linked with ventilator-induced lung injury.Methods: Two groups of BALB/c mice (n = 8 per group) were ventilated for 2 h using a protective or injurious ventilation strategy, with free-breathing mice as controls. Regional VT and FRC of the ventilated mice was determined from analysis of high-resolution four-dimensional computed tomography (4D-CT) images, taken at baseline and after 2 h of ventilation and corrected for the volume of the region (i.e. specific [s]Vt and specific [s]FRC). RNA levels of 21 genes in ten different lung regions were quantified using qPCR array.Results: sFRC at baseline varied regionally, independent of ventilation strategy, whereas sVT varied regionally depending on ventilation strategy. The expression of IL-6 (P = 0.04), Ccl2 (P Conclusion: These observations suggest that regional inflammatory responses to mechanical ventilation are primarily driven by tidal stretch.

Item Type: Article
Authors/Creators:Yen, S and Preissner, M and Bennett, E and Dubsky, S and Carnibella, R and O'Toole, R and Roddam, L and Jones, H and Dargaville, PA and Fouras, A and Zosky, GR
Journal or Publication Title: American Journal of Respiratory Cell and Molecular Biology
Publisher: American Thoracic Society
ISSN: 1535-4989
DOI / ID Number: 10.1165/rcmb.2018-0143OC
Copyright Information:

Copyright © 2019 American Thoracic Society. Originally Published in: Yen, S and Preissner, M and Bennett, E and Dubsky, S and Carnibella, R and O'Toole, R and Roddam, L and Jones, H and Dargaville, PA and Fouras, A and Zosky, GR, The link between regional tidal stretch and lung injury during mechanical ventilation, American Journal of Respiratory Cell and Molecular Biology pp. 1-35. ISSN 1535-4989 (2018). The final publication is available at:

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