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The link between regional tidal stretch and lung injury during mechanical ventilation
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ORCID: 0000-0001-6208-3313, Preissner, M, Bennett, E ORCID: 0000-0002-9818-827X, Dubsky, S, Carnibella, R, O'Toole, R ORCID: 0000-0002-4579-4479, Roddam, L ORCID: 0000-0002-4152-0681, Jones, H, Dargaville, PA, Fouras, A and Zosky, GR ORCID: 0000-0001-9039-0302 2018
, 'The link between regional tidal stretch and lung injury during mechanical ventilation'
, American Journal of Respiratory Cell and Molecular Biology
, pp. 1-35
, doi: 10.1165/rcmb.2018-0143OC.
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Abstract
Aim: This study aimed to assess the association between regional tidal volume (VT), regional functional residual capacity (FRC) and the expression of genes linked with ventilator-induced lung injury.Methods: Two groups of BALB/c mice (n = 8 per group) were ventilated for 2 h using a protective or injurious ventilation strategy, with free-breathing mice as controls. Regional VT and FRC of the ventilated mice was determined from analysis of high-resolution four-dimensional computed tomography (4D-CT) images, taken at baseline and after 2 h of ventilation and corrected for the volume of the region (i.e. specific [s]Vt and specific [s]FRC). RNA levels of 21 genes in ten different lung regions were quantified using qPCR array.Results: sFRC at baseline varied regionally, independent of ventilation strategy, whereas sVT varied regionally depending on ventilation strategy. The expression of IL-6 (P = 0.04), Ccl2 (P Conclusion: These observations suggest that regional inflammatory responses to mechanical ventilation are primarily driven by tidal stretch.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Yen, S and Preissner, M and Bennett, E and Dubsky, S and Carnibella, R and O'Toole, R and Roddam, L and Jones, H and Dargaville, PA and Fouras, A and Zosky, GR |
| Journal or Publication Title: | American Journal of Respiratory Cell and Molecular Biology |
| Publisher: | American Thoracic Society |
| ISSN: | 1535-4989 |
| DOI / ID Number: | 10.1165/rcmb.2018-0143OC |
| Copyright Information: | Copyright © 2019 American Thoracic Society. Originally Published in: Yen, S and Preissner, M and Bennett, E and Dubsky, S and Carnibella, R and O'Toole, R and Roddam, L and Jones, H and Dargaville, PA and Fouras, A and Zosky, GR, The link between regional tidal stretch and lung injury during mechanical ventilation, American Journal of Respiratory Cell and Molecular Biology pp. 1-35. ISSN 1535-4989 (2018). The final publication is available at: |
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