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The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population

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Stierli, S, Napoli, I, White, IJ, Cattin, A-L, Monteza Cabrejos, A, Garcia Calavia, N, Malong, L, Ribeiro, S, Nihouarn, J, Williams, R, Young, KM ORCID: 0000-0002-1686-3463, Richardson, WD and Lloyd, AC 2018 , 'The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population' , Development, vol. 145, no. 24 , pp. 1-12 , doi: 10.1242/dev.170316.

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Abstract

Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of the central nervous system (CNS). Here, we show that adult peripheral nerve is a more quiescent tissue than the CNS, yet all cell types within a peripheral nerve proliferate efficiently following injury. Moreover, whereas oligodendrocytes are produced throughout life from a precursor pool, we find that the corresponding cell of the peripheral nervous system, the myelinating Schwann cell (mSC), does not turn over in the adult. However, following injury, all mSCs can dedifferentiate to the proliferating progenitor-like Schwann cells (SCs) that orchestrate the regenerative response. Lineage analysis shows that these newly migratory, progenitor-like cells redifferentiate to form new tissue at the injury site and maintain their lineage, but can switch to become a non-myelinating SC. In contrast, increased plasticity is observed during tumourigenesis. These findings show that peripheral nerves have a distinct mechanism for maintaining homeostasis and can regenerate without the need for an additional stem cell population.This article has an associated 'The people behind the papers' interview.

Item Type: Article
Authors/Creators:Stierli, S and Napoli, I and White, IJ and Cattin, A-L and Monteza Cabrejos, A and Garcia Calavia, N and Malong, L and Ribeiro, S and Nihouarn, J and Williams, R and Young, KM and Richardson, WD and Lloyd, AC
Keywords: CNS, PNS, schwann cells, stem cells, tissue homeostasis, tissue regeneration
Journal or Publication Title: Development
Publisher: Company Of Biologists Ltd
ISSN: 0950-1991
DOI / ID Number: 10.1242/dev.170316
Copyright Information:

© 2018. Published by The Company of Biologists Ltd. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

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