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Compression socks and the effects on coagulation and fibrinolytic activation during marathon running

Zadow, EK ORCID: 0000-0001-7740-3594, Adams, MJ ORCID: 0000-0002-7743-4515, Wu, SSX ORCID: 0000-0001-5087-8813, Kitic, CM ORCID: 0000-0001-9866-5665, Singh, I, Kundur, A, Bost, N, Johnston, ANB, Crilly, J, Bulmer, AC, Halson, SL and Fell, JW ORCID: 0000-0001-6094-9865 2018 , 'Compression socks and the effects on coagulation and fibrinolytic activation during marathon running' , European Journal of Applied Physiology, vol. 118, no. 10 , pp. 2171-2177 , doi: 10.1007/s00421-018-3929-5.

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Abstract

Purpose: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, whencombined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear.Objectives: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon.Methods: Sixty-seven participants [43 males (mean±SD: age: 46.7±10.3 year) and 24 females (age: 40.0±11.0 year)] wereallocated into a compression (SOCK, n=34) or control (CONTROL, n=33) group. Venous blood samples were obtained24 h prior to and immediately POST-marathon, and were analyzed for thrombin–anti-thrombin complex (TAT), tissue factor(TF), tissue factor pathway inhibitor (TFPI), and D-Dimer.Results: Compression significantly attenuated the post-exercise increase in D-Dimer compared to the control group [median(range) SOCK: +9.02 (−0.34 to 60.7) ng/mL, CONTROL: +25.48 (0.95–73.24) ng/mL]. TF increased following the marathon run [median (range), SOCK: +1.19 (−7.47 to 9.11) pg/mL, CONTROL: +3.47 (−5.01 to 38.56) pg/mL] in all runners.No significant post-exercise changes were observed for TAT and TFPI.Conclusions: While activation of coagulation and fibrinolysis was apparent in all runners POST-marathon, wearing compression socks was shown to reduce fibrinolytic activity, as demonstrated by lower D-Dimer concentrations. Compression mayreduce exercise-associated haemostatic activation when completing prolonged exercise.

Item Type: Article
Authors/Creators:Zadow, EK and Adams, MJ and Wu, SSX and Kitic, CM and Singh, I and Kundur, A and Bost, N and Johnston, ANB and Crilly, J and Bulmer, AC and Halson, SL and Fell, JW
Keywords: compression, D-dimer, Tissue factor, Tissue factor pathway inhibitor, Thrombin anti-thrombin complexes
Journal or Publication Title: European Journal of Applied Physiology
Publisher: Springer
ISSN: 1439-6319
DOI / ID Number: 10.1007/s00421-018-3929-5
Copyright Information:

Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature

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