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Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study

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Wu, J, Xu, J, Wang, K, Zhu, Q, Cai, J, Ren, J, Zheng, S ORCID: 0000-0003-3552-1247 and Ding, C ORCID: 0000-0002-9479-730X 2018 , 'Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study' , BMC Musculoskeletal Disorders, vol. 19, no. 1 , pp. 1-7 , doi: 10.1186/s12891-018-1936-7.

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Abstract

Background: Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of adipokines and BMD in patients with knee OA.Methods: This study included 164 patients with symptomatic knee OA from the Anhui Osteoarthritis study. Serum levels of leptin, adiponectin, and resistin were measured using an enzyme-linked immunosorbent assay (ELISA). BMD at total body, spine, hip, and femur were measured by dual-energy X-ray absorptiometry (DXA).Results: In multivariable analyses, serum levels of leptin were significantly associated with reduced BMD at total body, hip, total femur, femoral neck, and femoral shaft (β = - 0.019, 95% CI -0.034 to - 0.005; β = - 0.018, 95% CI -0.034 to - 0.003; β = - 0.018, 95% CI -0.034 to - 0.002; β = - 0.016, 95% CI -0.032 to 0.000; β = - 0.026, 95% CI -0.046 to - 0.006; respectively). Serum levels of adiponectin were significantly and negatively associated with BMD at total femur and femoral shaft (β = - 0.007, 95% CI -0.013 to 0.000; β = - 0.011, 95% CI -0.018 to - 0.003; respectively). However, no significant associations were found between serum levels of resistin and BMD at any site measured.Conclusions: Serum levels of leptin and adiponectin were significantly and negatively associated with BMD, suggesting potentially detrimental effects of leptin and adiponectin on BMD in knee OA patients.

Item Type: Article
Authors/Creators:Wu, J and Xu, J and Wang, K and Zhu, Q and Cai, J and Ren, J and Zheng, S and Ding, C
Keywords: adiponectin, bone mineral density, leptin, osteoarthritis, resistin
Journal or Publication Title: BMC Musculoskeletal Disorders
Publisher: Biomed Central Ltd
ISSN: 1471-2474
DOI / ID Number: 10.1186/s12891-018-1936-7
Copyright Information:

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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