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Abstract

Purpose: It has been suggested that female sex steroids have neuroprotective properties that may reduce risk of glaucoma in premenopausal women. In this study, we explored the associations of optic disc measures with female reproductive factors in a population of young women.Design: Cohort study.Methods: Young women (n = 494; age range, 18-22 years) were recruited as part of the Western Australian Pregnancy Cohort (Raine) Study. Information on age at menarche, parity, and use of hormonal contraceptives were obtained from questionnaires. Participants underwent an eye examination, including spectral-domain optical coherence tomography imaging, to obtain optic disc parameters.Results: Women who had given birth at least once (parous women; n = 10) had larger vertical neuroretinal rim widths (P P Conclusions: We found limited evidence that female reproductive factors were related with optic disc parameters during young adulthood. The association between parity and optic disc parameter, though significant, should be further investigated given the small number of parous women in the current sample. Future follow-ups of this cohort will allow us to explore for any associations of these factors with optic disc parameters and glaucoma risk at an older age.

Item Type:	Article
Authors/Creators:	Lee, SSY and Yazar, S and Pasquale, LR and Sanfilippo, PG and Hewitt, AW and Hickey, M and Skinner, R and Mackey, DA
Keywords:	Raine Study, female reproductive factors, glaucoma, oestrogens, optic disc
Journal or Publication Title:	Asia-Pacific Journal of Ophthalmology
Publisher:	Lippincott Williams & Wilkins
ISSN:	2162-0989
DOI / ID Number:	https://doi.org/10.22608/APO.2018329
Copyright Information:	Copyright 2018 Asia-Pacific Academy of Ophthalmology
Related URLs:	Google Scholar: Hewitt, AW UTAS Profile: Hewitt, AW
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