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Abstract

Primary open-angle glaucoma (POAG) is influenced by both genetic and environmental factors. Despite significant progress in identifying genetic variants associated with POAG, there remains a substantial amount of unexplained heritability. Study design features that may enhance knowledge of the genetic architecture include focusing on multiple quantitative traits related to ocular disorders (i.e. endophenotypes), targeting genetic variants that directly influence gene expression (i.e. cis-eQTLs) and utilising genetically isolated populations to reduce genetic and environmental noise and thus enhance association signals. In this study we performed heritability and blood-based eQTL association analysis of five key POAG endophenotypes in 330 individuals from the Norfolk Island (NI) isolate. Results showed evidence of heritability for all five traits, with H2 estimates ranging from 0.35 for intraocular pressure (IOP) to 0.82 for central corneal thickness (CCT) (P BTN3A2, whereby both cis-SNP and transcript were significantly associated with disc size within a conditional regression model. Specifically, this model included rs853676 (β = 0.23, P = 0.008) and transcript (β = 0.23, P = 0.03). We also observed a cis-SNP association between optic disc size and LPCAT2 independent of transcript (P = 0.0004). These genes have specific functions in immune system pathways and suggest a role for an inherited immune component of POAG risk. This study also demonstrates an alternate approach to understanding the functional genetic basis of POAG and ocular health more generally.

Item Type:	Article
Authors/Creators:	Fang Kho, P and Lea, RA and Benton, MC and Eccles, D and Haupt, LM and Hewitt, AW and Sherwin, JC and Mackey, DA and Griffiths, LR
Keywords:	glaucoma, open-angle, POAG patients
Journal or Publication Title:	Journal of Human Genetics
Publisher:	Nature Publishing Group
ISSN:	1434-5161
DOI / ID Number:	10.1038/s10038-017-0374-y
Copyright Information:	Copyright 2018 The Japan Society of Human Genetics
Related URLs:	Google Scholar: Hewitt, AW UTAS Profile: Hewitt, AW
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