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Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting

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Maklad, A and Sharma, A ORCID: 0000-0002-5161-8084 2019 , 'Calcium Signaling in Brain Cancers: Roles and Therapeutic Targeting' , Cancers, vol. 11, no. 2 , pp. 1-16 , doi: 10.3390/cancers11020145.

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Abstract

Calcium signaling, in addition to its numerous physiological roles, is also implicated inseveral pathological conditions including cancer. An increasing body of evidence suggest criticalroles of calcium signaling in the promotion of different aspects of cancer, including cell proliferation,therapy resistance and metastatic-related processes. In many cases, this is associated with alteredexpression and/or activity of some calcium channels and pumps. Brain cancers have also beenthe subject of many of these studies. In addition to diverse roles of calcium signals in normalbrain function, a number of proteins involved in calcium transport are implicated to have specificroles in some brain cancers including gliomas, medulloblastoma, neuroblastoma and meningioma.This review discusses research that has been conducted so far to understand diverse roles ofCa2+-transporting proteins in the progression of brain cancers, as well as any attempts to target theseproteins towards a therapeutic approach for the control of brain cancers. Finally, some knowledgegaps in the field that may need to be further considered are also discussed.

Item Type: Article
Authors/Creators:Maklad, A and Sharma, A
Keywords: calcium signalling, brain cancer
Journal or Publication Title: Cancers
Publisher: MDPIAG
ISSN: 2072-6694
DOI / ID Number: 10.3390/cancers11020145
Copyright Information:

Copyright 2019 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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