Full text not available from this repository.

Abstract

The microcirculation in adipose tissue is markedly impaired in type 2 diabetes (T2D). Resistance training (RT) often increases muscle mass and promotes a favourable metabolic profile in people with T2D, even in the absence of fat loss. Whether the metabolic benefits of RT in T2D are linked to improvements in adipose tissue microvascular blood flow is unknown. Eighteen sedentary people with T2D (7F/11M, 52±7 years) completed six weeks of RT. Before and after RT, overnight-fasted participants had blood sampled for clinical chemistries (glucose, insulin, lipids, HbA1c and pro-inflammatory markers), underwent an oral glucose challenge (OGC, 50g glucose x 2hr) and a DEXA scan to assess body composition. Adipose tissue microvascular blood volume and flow were assessed at rest and 1hr post-OGC using contrast-enhanced ultrasound. RT significantly reduced fasting blood glucose (p=0.006), HbA1c (p=0.007), 2-hr glucose area under the time curve post-OGC (p=0.014) and HOMA-IR (p=0.005). This was accompanied by a small reduction in total body fat (p=0.002), trunk fat (p=0.023) and fasting triglyceride levels (p=0.029). Lean mass (p=0.003), circulating TNFa (p=0.006) and soluble VCAM-1 (pr=-0.476, p=0.045). The anthropometric, glycemic and insulin sensitizing benefits of six weeks of RT in people with T2D are not associated with an improvement in adipose tissue microvascular responses, however there may be an adipose tissue microvascular-linked benefit to fasting triglyceride levels.

Item Type:	Article
Authors/Creators:	Hu, D and Russell, RD and Remash, D and Greenaway, T and Rattigan, S and Squibb, KA and Jones, G and Ross, RM and Roberts, CK and Premilovac, D and Richards, SM and Keske, MA
Keywords:	adipose tissue, exercise, metabolic physiology, microvascular blood flow, type 2 diabetes
Journal or Publication Title:	American Journal of Physiology: Endocrinology and Metabolism
Publisher:	Amer Physiological Soc
ISSN:	0193-1849
DOI / ID Number:	10.1152/ajpendo.00234.2018
Copyright Information:	Copyright 2018 APS
Related URLs:	UTAS Profile: Russell, RD UTAS Profile: Rattigan, S UTAS Profile: Squibb, KA Google Scholar: Jones, G UTAS Profile: Jones, G Google Scholar: Ross, RM UTAS Profile: Ross, RM Google Scholar: Premilovac, D UTAS Profile: Premilovac, D Google Scholar: Richards, SM UTAS Profile: Richards, SM UTAS Profile: Keske, MA
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page