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A novel method for assessing proximal tibiofibular joint on MR images in patients with knee osteoarthritis

Chang, J, Zhu, Z ORCID: 0000-0003-3913-2564, Liao, Z, Meng, T, Zheng, S ORCID: 0000-0003-3552-1247, Cicuttini, F, Winzenberg, T ORCID: 0000-0002-4112-3491, Wluka, A, Jiang, D ORCID: 0000-0002-7738-0078, Han, W ORCID: 0000-0003-1590-7433 and Ding, C ORCID: 0000-0002-9479-730X 2018 , 'A novel method for assessing proximal tibiofibular joint on MR images in patients with knee osteoarthritis' , Osteoarthritis and Cartilage, vol. 26, no. 12 , pp. 1675-1682 , doi: 10.1016/j.joca.2018.08.011.

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Abstract

Objectives: To validate a method to measure the morphological parameters of the proximal tibiofibular joint (PTFJ) in patients with knee osteoarthritis (OA).Methods: 408 participants were examined in this cross-sectional subject-based study. We calculated the fibular contacting area of PTFJ (S) and its projection areas onto the horizontal plane (load-bearing area, Sτ), the sagittal plane (lateral stress-bolstering area, Sφ) and the coronal plane (posterior stress-bolstering area, Sυ). Joint space narrowing (JSN) and osteophyte was measured using radiographs. Cartilage defects, bone marrow lesions (BMLs) and cartilage volume were evaluated using magnetic resonance imaging (MRI).Results: The average PTFJ fibular contacting area was 2.4 cm2 (SD, ±0.7 cm2). Intra-observer and inter-observer reliabilities of measures of PTFJ morphological parameters were excellent (≥0.90). S, Sτ and Sφ were significantly associated with JSN in the medial tibiofemoral compartment (PR: 1.40, 95% CI 1.10-1.78; PR: 1.65, 95% CI 1.25-2.18 and PR: 0.53, 95% CI 0.29-0.97, respectively). There was a significantly positive association between S, Sτ and medial and/or femoral tibial cartilage defects. S, Sτ and Sυ were significantly and positively associated with medial and/or femoral tibial BMLs (PR: 1.36, 95% CI 1.12-1.64; PR: 1.47, 95% CI 1.17-1.83; and PR: 1.39, 95% CI 1.06-1.82, respectively) after adjustment. S and Sτ were significantly and negatively associated with medial tibial cartilage volume.Conclusions: This novel method to assess the morphological parameters of PTFJ in MRI is reproducible. These parameters are associated with knee radiographic and MRI-based OA-related structural abnormalities, suggesting clinical construct validity. Its predictive validity needs to be examined in future longitudinal studies.

Item Type: Article
Authors/Creators:Chang, J and Zhu, Z and Liao, Z and Meng, T and Zheng, S and Cicuttini, F and Winzenberg, T and Wluka, A and Jiang, D and Han, W and Ding, C
Keywords: knee osteoarthritis, MR images, proximal tibiofibular joint
Journal or Publication Title: Osteoarthritis and Cartilage
Publisher: W B Saunders Co Ltd
ISSN: 1063-4584
DOI / ID Number: 10.1016/j.joca.2018.08.011
Copyright Information:

Copyright 2018 Osteoarthritis Research Society International

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