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Sex bias in ability to cope with cancer: Tasmanian devils and facial tumour disease

Ruiz-Aravena, MI ORCID: 0000-0001-8463-7858, Jones, ME ORCID: 0000-0001-7558-9022, Carver, SS ORCID: 0000-0002-3579-7588, Estay, S, Espejo, C, Storfer, A and Hamede, RK ORCID: 0000-0003-1526-225X 2018 , 'Sex bias in ability to cope with cancer: Tasmanian devils and facial tumour disease' , Proceedings of the Royal Society B: Biological Sciences, vol. 285, no. 1891 , pp. 1-7 , doi: 10.1098/rspb.2018.2239.

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Abstract

Knowledge of the ecological dynamics between hosts and pathogens during the initial stages of disease emergence is crucial to understanding the potential for evolution of new interspecific interactions. Tasmanian devil (Sarcophilus harrisii) populations have declined precipitously owing to infection by a transmissible cancer (devil facial tumour disease, DFTD) that emerged approximately 20 years ago. Since the emergence of DFTD, and as the disease spreads across Tasmania, the number of devils has dropped up to 90% across 80% of the species's distributional range. As a result, the disease is expected to act as a strong selective force on hosts to develop mechanisms of tolerance and/or resistance to the infection. We assessed the ability of infected devils to cope with infection, which translates into host tolerance to the cancer, by using the reaction norm of the individual body condition by tumour burden. We found that body condition of infected hosts is negatively affected by cancer progression. Males and females presented significant differences in their tolerance levels to infection, with males suffering declines of up to 25% of their body condition, in contrast to less than 5% in females. Sex-related differences in tolerance to cancer progression may select for changes in life-history strategies of the host and could also alter the selective environment for the tumours.

Item Type: Article
Authors/Creators:Ruiz-Aravena, MI and Jones, ME and Carver, SS and Estay, S and Espejo, C and Storfer, A and Hamede, RK
Keywords: wildlife disease, Tasmanian devil facial tumour disease, host-pathogen, cope with infection, tolerance to infection, DFTD
Journal or Publication Title: Proceedings of the Royal Society B: Biological Sciences
Publisher: Royal Soc London
ISSN: 0962-8452
DOI / ID Number: 10.1098/rspb.2018.2239
Copyright Information:

Copyright 2018 The Authors

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