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Gefitinib for advanced non-small cell lung cancer

Sim, EHA, Yang, IA, Wood-Baker, R, Bowman, RV and Fong, KM 2018 , 'Gefitinib for advanced non-small cell lung cancer' , Cochrane Database of Systematic Reviews, vol. 2018, no. 1 , pp. 1-265 , doi:

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Background: The role of gefitinib for the treatment of advanced non-small cell lung cancer (NSCLC) is evolving. We undertook a systematic review to evaluate the available evidence from all randomised trials. Objectives: To determine the effectiveness and safety of gefitinib as first-line, second-line or maintenance treatment for advanced NSCLC. Search methods: We performed searches in CENTRAL, MEDLINE and Embase from inception to 17 February 2017. We handsearched relevant conference proceedings, clinical trial registries and references lists of retrieved articles. Selection criteria: We included trials assessing gefitinib, alone or in combination with other treatment, compared to placebo or other treatments in the first- or successive-line treatment of patients with NSCLC, excluding compassionate use. Data collection and analysis: We used the standard Cochrane methodology. Two authors independently assessed the search results to select those with sound methodological quality. We carried out all analyses on an intention-to-treat basis. We recorded the following outcome data: overall survival, progression-free survival, toxicity, tumour response and quality of life. We also collected data for the following subgroups: Asian ethnicity and positive epidermal growth factor receptor (EGFR) mutation. Main results: We included 35 eligible randomised controlled trials (RCTs), which examined 12,089 patients.

Item Type: Article
Authors/Creators:Sim, EHA and Yang, IA and Wood-Baker, R and Bowman, RV and Fong, KM
Journal or Publication Title: Cochrane Database of Systematic Reviews
Publisher: Vista
ISSN: 1469-493X
DOI / ID Number:
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Copyright © 2018 The Cochrane Collaboration.

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