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Effect of sex on vaccination outcomes: important but frequently overlooked

Harper, A and Flanagan, K 2018 , 'Effect of sex on vaccination outcomes: important but frequently overlooked' , Current Opinion in Pharmacology, vol. 41 , pp. 122-127 , doi: 10.1016/j.coph.2018.05.009.

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Abstract

It is well established that vaccination does not affect males and females equally. For example, females generally mount greater antibody responses to vaccination than males, but also suffer more adverse events following vaccination, probably as a result of more robust immunity. Despite this, most researchers in the field of vaccinology do not take biological sex into account when conducting their studies. This omission is likely to lead to a loss of important information in terms of both reactogenicity and immunogenicity following vaccination as well as those suffering adverse events. It also suggests that the vaccine dose in males and females may need to be different in order to achieve the same outcome of protective immunity while minimising reactogenicity.

Item Type: Article
Authors/Creators:Harper, A and Flanagan, K
Journal or Publication Title: Current Opinion in Pharmacology
Publisher: Elsevier Science Ltd.
ISSN: 1471-4892
DOI / ID Number: 10.1016/j.coph.2018.05.009
Copyright Information:

Crown Copyright 2018 Published by Elsevier Ltd. All rights reserved.

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