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The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

Morganti-Kossmann, MC, Semple, BD, Hellewell, SC, Bye, N ORCID: 0000-0003-0976-5870 and Ziebell, JM ORCID: 0000-0003-2497-4347 2018 , 'The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments' , Acta Neuropathologica , pp. 1-25 , doi: 10.1007/s00401-018-1944-6.

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Abstract

This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured brain following trauma. We summarise the literature fluctuating from the protective and detrimental properties that cytokines, leukocytes and glial cells play in the acute and chronic stages of TBI, including the intrinsic factors that influence cytokine responses and microglial functions relative to genetics, sex, and age. We elaborate on the pros and cons that cytokines, chemokines, and microglia play in brain repair, specifically neurogenesis, and how such conflicting roles may be harnessed therapeutically to sustain the survival of new neurons. With a brief review of the clinical and experimental findings demonstrating early and chronic inflammation impacts on outcomes, we focus on the clinical conditions that may be amplified by neuroinflammation, ranging from acute seizures to chronic epilepsy, neuroendocrine dysfunction, dementia, depression, post-traumatic stress disorder and chronic traumatic encephalopathy. Finally, we provide an overview of the therapeutic agents that have been tested to reduce inflammation-driven secondary pathological cascades and speculate the future promise of alternative drugs.

Item Type: Article
Authors/Creators:Morganti-Kossmann, MC and Semple, BD and Hellewell, SC and Bye, N and Ziebell, JM
Keywords: traumatic brain injury, microglia, inflammation, astrocytes
Journal or Publication Title: Acta Neuropathologica
Publisher: Springer-Verlag
ISSN: 0001-6322
DOI / ID Number: 10.1007/s00401-018-1944-6
Copyright Information:

Copyright 2018 Springer-Verlag GmbH Germany, part of Springer Nature

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