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Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode

May, T and Pridmore, S ORCID: 0000-0002-9170-1798 2019 , 'Impact of transcranial magnetic stimulation on the symptom profile of major depressive episode' , Australasian Psychiatry , pp. 1-5 , doi:

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Objectives: This study aimed to explore the effects of a four-week course of transcranial magnetic stimulation (TMS)on the following symptoms of major depressive episode (MDE): mood, work activities, health concerns, guilt, anxietyand retardation.Method: Patients underwent 20 daily sessions of 10 Hz TMS (two sets of 10 daily treatments separated by two daysof rest). The six-item Hamilton Depression Rating Scale (HAMD-6) was administered before and after treatment.Remission was operationalised as a HAMD-6 score of Results: There were 104 participants (79 female; 76%), with a mean age of 44.6 years (SD=15.7 years). There was asignificant improvement in the whole sample and in remitters (n=70) on all subscales. However, those who failedto remit did not achieve significant reductions in ‘health concerns’ and ‘retardation’. There were no difference inage and sex between remitters and non-remitters. Also, there were no significant differences between the remittersand non-remitters on the pretreatment depression symptom profiles. No predictors of response were identified, asexpected.Conclusions: TMS has the ability to reduce all listed MDE symptoms. No pretreatment MDE symptom profile wasidentified which might carry prognostic value.

Item Type: Article
Authors/Creators:May, T and Pridmore, S
Keywords: major depressive disorder, transcranial magnetic stimulation, symptom profile, Hamilton Depression Rating Scale
Journal or Publication Title: Australasian Psychiatry
Publisher: Sage Publications Ltd.
ISSN: 1039-8562
DOI / ID Number:
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