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Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults

Balogun, S ORCID: 0000-0001-6415-5536, Winzenberg, T ORCID: 0000-0002-4112-3491, Wills, K ORCID: 0000-0003-3897-2908, Scott, DS, Jones, G ORCID: 0000-0002-9814-0006, Callisaya, ML ORCID: 0000-0003-2122-1622 and Aitken, D ORCID: 0000-0001-5685-7634 2019 , 'Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults' , Experimental Gerontology, vol. 118 , pp. 65-71 , doi:

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Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults.Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. HRQoL was measured using the validated assessment of quality of life (AQoL) instrument. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry and normalized to body mass index (BMI). HGS and LMS were assessed using dynamometers. Low ALM/BMI (ALM/BMILOW), LMS (LMSLOW) and HGS (HGSLOW) at baseline were defined as the lowest 20% of the sex-specific distribution for each measure. Linear mixed effect regression models, adjusting for confounders, were used to estimate the association between ALM/BMILOW, LMSLOW, and HGSLOW at baseline and HRQoL over 10 years.Results: Participants with LMSLOW (β = -0.061, 95% CI: -0.089, -0.033) and women (β = -0.089, 95% CI: -0.129, -0.049) but not men (β = -0.023, 95% CI: -0.064, 0.019) with HGSLOW had clinically meaningful reductions in HRQoL over 10 years compared to those with normal strength. There was a weaker but statistically significant association between ALM/BMILOW and 10-year HRQoL (β = -0.038, 95% CI: -0.068, -0.008).Conclusions: Lower-limb muscle strength and handgrip strength (in women only), which can be easily measured in clinical practice, appear more important than muscle mass for HRQoL.

Item Type: Article
Authors/Creators:Balogun, S and Winzenberg, T and Wills, K and Scott, DS and Jones, G and Callisaya, ML and Aitken, D
Keywords: body composition, health-related quality of life, muscle mass, muscle strength
Journal or Publication Title: Experimental Gerontology
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0531-5565
DOI / ID Number:
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Copyright 2019 Elsevier Inc.

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