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The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies

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Beard, DJ, Hadley, G, Thurley, N, Howells, DW ORCID: 0000-0002-2512-7724, Sutherland, BA ORCID: 0000-0002-0791-0950 and Buchan, AM 2019 , 'The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies' , International journal of stroke, vol. 14, no. 2 , pp. 137-145 , doi: 10.1177/1747493018816503.

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Abstract

Background:Amplifying endogenous neuroprotective mechanisms is a promising avenue for stroke therapy. One target is mammalian target of rapamycin (mTOR), a serine/threonine kinase regulating cell proliferation, cell survival, protein synthesis, and autophagy. Animal studies investigating the effect of rapamycin on mTOR inhibition following cerebral ischemia have shown conflicting results.Aim:To conduct a systematic review and meta-analysis evaluating the effectiveness of rapamycin in reducing infarct volume in animal models of ischemic stroke.Summary of review:Our search identified 328 publications. Seventeen publications met inclusion criteria (52 comparisons: 30 reported infarct size and 22 reported neurobehavioral score). Study quality was modest (median 4 of 9) with no evidence of publication bias. The point estimate for the effect of rapamycin was a 21.6% (95% CI, 7.6%–35.7% p Conclusion:Low-dose rapamycin treatment may be an effective therapeutic option for stroke. Modest study quality means there is a potential risk of bias. We recommend further high-quality preclinical studies on rapamycin in stroke before progressing to clinical trials.

Item Type: Article
Authors/Creators:Beard, DJ and Hadley, G and Thurley, N and Howells, DW and Sutherland, BA and Buchan, AM
Keywords: stroke, rapamycin, mtor, neuroprotection, blood flow
Journal or Publication Title: International journal of stroke
Publisher: Sage Publications Ltd.
ISSN: 1747-4930
DOI / ID Number: 10.1177/1747493018816503
Copyright Information:

Copyright 2018 World Stroke Organization

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