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Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample

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Liu, E, Kaidonis, G, Gillies, MC, Abhary, S, Essex, RW, Chang, JH, Pal, B, Daniell, M, Lake, S, Gilhotra, J, Petrovsky, N, Hewitt, AW, Jenkins, A, Lamoureux, EL, Gleadle, JM, Burdon, KP ORCID: 0000-0001-8217-1249 and Craig, JE 2019 , 'Mitochondrial haplogroups are not associated with diabetic retinopathy in a large Australian and British Caucasian sample' , Scientific Reports, vol. 9, no. 1 , pp. 1-7 , doi: 10.1038/s41598-018-37388-8.

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Abstract

Mitochondrial haplogroups H1, H2 and UK have previously been reported to be associated with proliferative diabetic retinopathy (PDR) in Caucasian patients with diabetes. We aimed to replicate this finding with a larger sample and expand the analysis to include different severities of DR, and diabetic macular edema (DME). Caucasian participants (n = 2935) with either type 1 or type 2 diabetes from the Australian Registry of Advanced Diabetic Retinopathy were enrolled in this study. Twenty-two mitochondrial single nucleotide polymorphisms were genotyped by MassArray and haplogroups reconstructed using Haplogrep. Chi square tests and logistic regressions were used to test associations between haplogroup and DR phenotypes including any DR, non-proliferative DR (NPDR), proliferative DR (PDR) and DME. After stratifying the samples in type 1 and type 2 diabetes groups, and adjusting for sex, age, diabetes duration, concurrent HbA1c and hypertension, neither haplogroups H1, H2, UK, K or JT were associated with any DR, NPDR, PDR or DME.

Item Type: Article
Authors/Creators:Liu, E and Kaidonis, G and Gillies, MC and Abhary, S and Essex, RW and Chang, JH and Pal, B and Daniell, M and Lake, S and Gilhotra, J and Petrovsky, N and Hewitt, AW and Jenkins, A and Lamoureux, EL and Gleadle, JM and Burdon, KP and Craig, JE
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
DOI / ID Number: 10.1038/s41598-018-37388-8
Copyright Information:

Copyright 2019 the authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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