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Abstract

Context: Vitamin D plays a role in the differentiation and metabolism of skeletal muscle and, possibly, adipose tissue; however, the relationship between vitamin D status during growth and body composition in early adulthood is unclear.Objective: We examined associations between vitamin D status in childhood, adolescence, and early adulthood with body composition at age 20 years.Design Setting Participants: We studied 821 offspring (385 females) of the Western Australian Pregnancy Cohort Study who had ≥3 serum 25-hydroxyvitamin D [25(OH)D] at age 6, 14, 17, and 20 years and body composition assessed at age 20 using dual-energy x-ray absorptiometry. The participants were grouped into four vitamin D status trajectories: consistently lower, decreasing, increasing, and consistently higher.Results: The mean serum 25(OH)D at the study visits was 72.7 to 86.8 nmol/L. In males, serum 25(OH)D at 17 and 20 years was positively associated with lean body mass (LBM), and 25(OH)D at age 20 correlated negatively with fat body mass (FBM). Males with a consistently higher 25(OH)D trajectory had a 2.3- to 3.7-kg greater LBM and 4.1- to 6.0-kg lower FBM at 20 years compared with those with consistently lower or decreasing trajectories (P P Conclusions: In the present predominantly white, relatively vitamin D-replete cohort, a higher vitamin D status trajectory from childhood to early adulthood was associated with a greater LBM in males and lower FBM in both sexes at age 20.

Item Type:	Article
Authors/Creators:	Zhu, K and Oddy, WH and Holt, P and Ping-Delfos, WCS and McVeigh, J and Straker, L and Mori, TA and Lye, S and Pennell, C and Walsh, JP
Keywords:	25-hydroxyvitamin D, Raine study, body composition, fat body mass, lean body mass, young adults
Journal or Publication Title:	Journal of the Endocrine Society
Publisher:	Oxford University Press
ISSN:	2472-1972
DOI / ID Number:	10.1210/js.2018-00349
Copyright Information:	Copyright 2019 Endocrine Society
Related URLs:	Google Scholar: Oddy, WH
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