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The effect of hospitalization on potentially inappropriate medication use in older adults with chronic kidney disease

Tesfaye, WH ORCID: 0000-0001-7208-2330, Wimmer, BC ORCID: 0000-0003-3166-7126, Peterson, GM ORCID: 0000-0002-6764-3882, Castelino, RL, Jose, MD ORCID: 0000-0002-9589-0071, McKercher, C ORCID: 0000-0002-7672-6743 and Zaidi, STR ORCID: 0000-0002-2031-1055 2018 , 'The effect of hospitalization on potentially inappropriate medication use in older adults with chronic kidney disease' , Current Medical Research and Opinion , pp. 1-18 , doi: 10.1080/03007995.2018.1560193.

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Objectives: Potentially inappropriate medication (PIM) use is associated with increased morbidity andmortality in chronic kidney disease (CKD). However, there is a paucity of data on how hospitalizationaffects PIM use in older adults with CKD. Therefore, we aimed to measure the impact of hospitalizationon PIM use in older CKD patients, and identify factors predicting PIM use.Methods: A retrospective cohort study was conducted in older adults (>=65 years) with CKD admittedto an Australian tertiary care hospital over a 6 month period. PIM use was measured, upon admissionand at discharge, using the Medication Appropriateness Index (MAI) and Beers criteria (2015 version)for medications recommended to be avoided in older adults and under certain conditions.Results: The median age of the 204 patients was 83 years (interquartile range (IQR): 76–87 years) andmost were men (61%). Overall, the level of PIM use (MAI) decreased from admission to discharge(median [IQR]: 6 [3–12] to 5 [2–9]; p p Conclusions: PIMs were commonly used in older CKD patients. Hospitalization was associated with areduction in PIM use, but there was considerable scope for improvement in these susceptibleindividuals.

Item Type: Article
Authors/Creators:Tesfaye, WH and Wimmer, BC and Peterson, GM and Castelino, RL and Jose, MD and McKercher, C and Zaidi, STR
Keywords: Beers criteria, medication appropriateness index, chronic kidney disease, elderly, potentially inappropriate medications
Journal or Publication Title: Current Medical Research and Opinion
Publisher: Librapharm
ISSN: 0300-7995
DOI / ID Number: 10.1080/03007995.2018.1560193
Copyright Information:

Copyright 2019 Informa UK Limited, trading as Taylor & Francis GroupThis is an Accepted Manuscript of an article published by Taylor & Francis in Current Medical Research and Opinion on 11 January 2019, available online:

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