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Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: a cohort study

Perret, JL, Matheson, MC, Gurrin, LC, Johns, DP ORCID: 0000-0002-1575-6850, Burgess, JA, Thompson, BR, Lowe, AJ, Markos, J, Morrison, SS, McDonald, CF, Wood-Baker, R, Svanes, C, Thomas, PS, Hopper, JL, Giles, GG, Abramson, MJ, Walters, EH ORCID: 0000-0002-0993-4374 and Dharmage, SC 2018 , 'Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: a cohort study' , Respirology, vol. 23, no. 8 , pp. 780-787 , doi: 10.1111/resp.13297.

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Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) has potential origins in childhoodbut an association between childhood measles and postbronchodilator (BD) airflow obstruction (AO) has notyet been shown. We investigated whether childhoodmeasles contributed to post-BD AO through interactionswith asthma and/or smoking in a non-immunizedmiddle-aged population.Methods: The population-based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961(n = 8583) underwent spirometry in 1968 before immunization was introduced. A history of childhood measlesinfection was obtained from school medical records.During the fifth decade follow-up (n = 5729 responses),a subgroup underwent further lung function measurements (n = 1389). Relevant main associations and interactions by asthma and/or smoking on post-BD forcedexpiratory volume in 1 s/forced vital capacity (FEV1/FVC; continuous variable) and AO (FEV1/FVC Results: Sixty‐nine percent (n = 950) had a history of childhood measles. Childhood measles augmented the combined adverse effect of current clinical asthma and smoking at least 10 pack‐years on post‐BD FEV1/FVC ratio in middle age (z‐score: −0.70 (95% CI: −1.1 to −0.3) vs −1.36 (−1.6 to −1.1), three‐way interaction: P = 0.009), especially for those with childhood‐onset asthma. For never‐ and ever‐smokers of Conclusion: Childhood measles infection appears tocompound the associations between smoking, currentasthma and post-BD AO. Differences between asthmasubgroups provide further insight into the complex aetiology of obstructive lung diseases for middle-aged adults.

Item Type: Article
Authors/Creators:Perret, JL and Matheson, MC and Gurrin, LC and Johns, DP and Burgess, JA and Thompson, BR and Lowe, AJ and Markos, J and Morrison, SS and McDonald, CF and Wood-Baker, R and Svanes, C and Thomas, PS and Hopper, JL and Giles, GG and Abramson, MJ and Walters, EH and Dharmage, SC
Keywords: asthma-COPD overlap, childhood measles, current adult asthma, interaction, smoking
Journal or Publication Title: Respirology
Publisher: Blackwell Science
ISSN: 1323-7799
DOI / ID Number: 10.1111/resp.13297
Copyright Information:

Copyright 2018 Asian Pacific Society of Respirology

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