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Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood

Cuthbertson, DJ, Brown, E, Koskinen, J, Magnussen, CG ORCID: 0000-0002-6238-5730, Hutri-Kahonen, N, Sabin, M, Tossavainen, P, Jokinen, E, Laitinen, T, Viikari, J, Raitakari, OT and Juonala, M 2019 , 'Longitudinal analysis of risk of non-alcoholic fatty liver disease in adulthood' , Liver International , pp. 1-8 , doi: 10.1111/liv.13993.

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Abstract

Background & Aims: We aimed to determine how childhood body mass index and metabolic health, along with the change in body mass index between childhood and adulthood, determine the risk of adult non-alcoholic fatty liver disease.Methods: Data from 2020 participants aged 3-18 years at baseline, followed up 31 years later, were examined to assess the utility of four childhood metabolic phenotypes (Metabolic Groups I: normal body mass index, no metabolic disturbances; II: normal body mass index, one or more metabolic disturbances; III: overweight/obese, no metabolic disturbances; IV: overweight/obese, one or more metabolic disturbances) and four life-course adiposity phenotypes (Adiposity Group 1: normal child and adult body mass index; 2, high child, normal adult body mass index; 3, normal child body mass index, high adult body mass index; 4, high child and adult body mass index) in predicting adult non-alcoholic fatty liver disease.Results: The risk for adult non-alcoholic fatty liver disease was similar across all four groups after adjustment for age, sex, lifestyle factors and adult body mass index. Risk of adult non-alcoholic fatty liver disease was not increased among individuals overweight/obese in childhood but non-obese in adulthood. In contrast, overweight or obese adults, irrespective of their youth body mass index status, had ~eight-fold to 10-fold increased risk (P Conclusions: Childhood overweight/obesity, not metabolic health, is associated with increased risk for adult non-alcoholic fatty liver disease. However, the increased risk associated with childhood overweight/obesity can be largely removed by obtaining a normal body mass index by adulthood.

Item Type: Article
Authors/Creators:Cuthbertson, DJ and Brown, E and Koskinen, J and Magnussen, CG and Hutri-Kahonen, N and Sabin, M and Tossavainen, P and Jokinen, E and Laitinen, T and Viikari, J and Raitakari, OT and Juonala, M
Keywords: metabolic health, non-alcoholic fatty liver disease, obesity, risk
Journal or Publication Title: Liver International
Publisher: Wiley-Blackwell Publishing Ltd.
ISSN: 1478-3223
DOI / ID Number: 10.1111/liv.13993
Copyright Information:

Copyright 2018 John Wiley & Sons A/S.

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