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Sex differences in left ventricular afterload and diastolic function are independent from the aortic size


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Sorimachi, H, Kurosawa, K, Yoshida, Kuniko, Obokata, M, Noguchi, T, Naka, M, Tange, S, Kurabayashi, M and Negishi, K ORCID: 0000-0002-9086-2565 2019 , 'Sex differences in left ventricular afterload and diastolic function are independent from the aortic size' , PLoS One, vol. 4, no. 4 , pp. 1-18 , doi: 10.1371/journal.pone.0214907.

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Background: Women have a greater risk of heart failure with preserved ejection fraction (HFPEF) than men do, yet the basis for this disparity remains unclear. Greater arterial stiffness and afterload causes left ventricular (LV) diastolic dysfunction, a central mechanism of HFPEF. Because of smaller body habitus, previous reports have used body surface area as a surrogate of the size of the aorta. We performed a comprehensive hemodynamic evaluation of elderly patients with preserved EF and evaluated sex differences in the associations between LV function and afterload, before and after adjusting for the aortic sizes.Methods and Results: Four hundred and forty-three patients (mean age: 73 years, 169 women) who underwent clinically indicated echocardiography and computed tomography (CT) were identified. Linear regression analyses were performed to assess the independent contributions of sex to and its interaction with LV function before and after adjusting for CT-derived aortic length and volume. Although blood pressures were similar between the sexes, women had greater arterial elastance, lower arterial compliance, and greater LV ejection fraction (all pConclusion: Women had worse LV relaxation than men did against the same degree of afterload, before and even after adjusting for the aortic sizes.

Item Type: Article
Authors/Creators:Sorimachi, H and Kurosawa, K and Yoshida, Kuniko and Obokata, M and Noguchi, T and Naka, M and Tange, S and Kurabayashi, M and Negishi, K
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
DOI / ID Number: 10.1371/journal.pone.0214907
Copyright Information:

Copyright 2019 Sorimachi et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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