Full text not available from this repository.

Abstract

Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre-lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI-rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI-rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI-rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.

Item Type:	Article
Authors/Creators:	Cullen, CL and Senesi, M and Tang, AD and Clutterbuck, MT and Auderset, LF and O'Rourke, ME and Rodger, J and Young, KM
Keywords:	adaptive myelination, cortex, internode, myelin, oligodendrocyte survival, oligodendrogenesis, transcranial magnetic stimulation
Journal or Publication Title:	Glia
Publisher:	Wiley-Liss
ISSN:	0894-1491
DOI / ID Number:	https://doi.org/10.1002/glia.23620
Copyright Information:	Copyright 2019 Wiley Periodicals, Inc.
Related URLs:	Google Scholar: Cullen, CL UTAS Profile: Cullen, CL UTAS Profile: Young, KM
Item Statistics:	View statistics for this item

Actions (login required)

Item Control Page