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Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain

Cullen, CL ORCID: 0000-0001-6929-6258, Senesi, M ORCID: 0000-0002-3968-2075, Tang, AD, Clutterbuck, MT, Auderset, L, O'Rourke, ME, Rodger, J and Young, KM ORCID: 0000-0002-1686-3463 2019 , 'Low-intensity transcranial magnetic stimulation promotes the survival and maturation of newborn oligodendrocytes in the adult mouse brain' , Glia , pp. 1-16 , doi: 10.1002/glia.23620.

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Abstract

Neuronal activity is a potent extrinsic regulator of oligodendrocyte generation and central nervous system myelination. Clinically, repetitive transcranial magnetic stimulation (rTMS) is delivered to noninvasively modulate neuronal activity; however, the ability of rTMS to facilitate adaptive myelination has not been explored. By performing cre-lox lineage tracing, to follow the fate of oligodendrocyte progenitor cells in the adult mouse brain, we determined that low intensity rTMS (LI-rTMS), administered as an intermittent theta burst stimulation, but not as a continuous theta burst or 10 Hz stimulation, increased the number of newborn oligodendrocytes in the adult mouse cortex. LI-rTMS did not alter oligodendrogenesis per se, but instead increased cell survival and enhanced myelination. These data suggest that LI-rTMS can be used to noninvasively promote myelin addition to the brain, which has potential implications for the treatment of demyelinating diseases such as multiple sclerosis.

Item Type: Article
Authors/Creators:Cullen, CL and Senesi, M and Tang, AD and Clutterbuck, MT and Auderset, L and O'Rourke, ME and Rodger, J and Young, KM
Keywords: adaptive myelination, cortex, internode, myelin, oligodendrocyte survival, oligodendrogenesis, transcranial magnetic stimulation
Journal or Publication Title: Glia
Publisher: Wiley-Liss
ISSN: 0894-1491
DOI / ID Number: 10.1002/glia.23620
Copyright Information:

Copyright 2019 Wiley Periodicals, Inc.

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