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Stability of milrinone in continuous ambulatory delivery devices

Al Madfai, F, Zaidi, STR ORCID: 0000-0002-2031-1055, Ming, LC ORCID: 0000-0002-6971-1383, Wanandy, T ORCID: 0000-0003-4703-0488 and Patel, RP ORCID: 0000-0001-9344-1013 2018 , 'Stability of milrinone in continuous ambulatory delivery devices' , American Journal of Health-System Pharmacy, vol. 75, no. 9 , e241-e245 , doi: 10.2146/ajhp170372.

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Abstract

Purpose: The stability of milrinone in continuous ambulatory delivery devices (CADDs) stored at 4, 25, and 35 °C was evaluated.Method: Six CADDs (3 devices containing milrinone plus 0.9% sodiumchloride injection and 3 devices containing milrinone plus 5% dextroseinjection) were prepared. Devices were kept at 4 °C for 168 hours, followedby 24 hours at 25 °C and an additional 24 hours at 35 °C. Samples (n = 3)were withdrawn aseptically at 0, 24, 48, 72, 96, 120, 144, and 168 hoursfrom the CADDs stored at 4 °C and at 0, 6, and 24 hours from the CADDsstored at 25 and 35 °C. The milrinone concentration of each aliquot wasanalyzed using a stability-indicating high performance liquid chromatographic method within 15–30 minutes of preparation. The samples werealso evaluated for changes in pH, changes in color, and particulate content. Six control samples (3 containing 0.9% sodium chloride injection and3 containing 5% dextrose injection) were prepared and similarly analyzed.Results: Milrinone admixtures retained more than 99% of their initial concentration for 168 hours at 4 °C and for 24 hours when stored at 25 and35 °C. No evidence of particle formation, color change, or pH change wasobserved throughout the study period.Conclusion: Milrinone 600 mg/mL prepared in either 0.9% sodium chloride injection or 5% dextrose injection in CADDs was stable for 168 hourswhen stored at 4 °C and for 24 hours when stored at 25 and 35 °C.

Item Type: Article
Authors/Creators:Al Madfai, F and Zaidi, STR and Ming, LC and Wanandy, T and Patel, RP
Keywords: Stability, HPLC, Milrinone, CADD
Journal or Publication Title: American Journal of Health-System Pharmacy
Publisher: Amer Soc Health-System Pharmacists
ISSN: 1079-2082
DOI / ID Number: 10.2146/ajhp170372
Copyright Information:

Copyright 2018, American Society of Health-System Pharmacists, Inc.

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