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Abstract

The Membrane Attack Complex Perforin-like/Cholesterol-Dependent Cytolysin (MACPF) superfamily is an ancient and biologically diverse group of proteins that are best known for pore-forming roles in mammalian immunity and bacterial pathogenesis. Intriguingly, however, some eukaryotic proteins which contain the MACPF domain that defines this family do not act in attack or defence, and instead have distinct developmental functions. It remains unclear whether these proteins function via pore formation or have a different mechanism of action. Of these, by far the best characterised is Torso-like (Tsl), the only MACPF member that has been identified in the fruit fly, Drosophila melanogaster. While it has long been known to have a role in embryonic patterning, recent studies have shown that Tsl in fact has multiple roles in development. As such, it presents an excellent opportunity to investigate how the MACPF domain functions in a developmental context. Here, we review what is known about Tsl in Drosophila and other insects, and discuss the potential molecular mechanism by which Tsl and thus other developmental MACPF proteins may function. © 2017 Elsevier Ltd

Item Type:	Article
Authors/Creators:	Johnson, TK and Henstridge, MA and Warr, C
Keywords:	Development; Drosophila; Growth; MACPF; Patterning; Torso-like; cholesterol dependent cytolysin; complement membrane attack complex; cytolysin; unclassified drug; cholesterol; complement membrane attack complex; cytotoxin; Drosophila protein; Review
Journal or Publication Title:	Seminars in Cell and Developmental Biology
Publisher:	Academic Press Ltd Elsevier Science Ltd
ISSN:	1084-9521
DOI / ID Number:	https://doi.org/10.1016/j.semcdb.2017.05.003
Copyright Information:	Copyright 2017 Elsevier Ltd.
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