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Rod microglia and their role in neurological diseases

Holloway, OG ORCID: 0000-0001-8129-6015, Canty, AJ ORCID: 0000-0001-5165-2365, King, AE ORCID: 0000-0003-1792-0965 and Ziebell, JM ORCID: 0000-0003-2497-4347 2019 , 'Rod microglia and their role in neurological diseases' , Seminars in Cell and Developmental Biology , doi:

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The striking morphology of microglia is one of their most prominent characteristics, with many studies categorising microglial function based on morphology e.g. ramified, hyper-ramified, activated, or amoeboid. Communications regarding rod microglia in neurological disease are scant, and where reported, these cells are rarely the focus of discussion. These factors make it difficult to determine how widespread these cells are not only through the brain but also across diseases. Studies in experimental diffuse brain injury are the first reports of not only significant numbers of rod microglia, but distinct arrangements of these cells, reminiscent of carriages of a train. This review summarises the available reports of rod microglia in vivo and rod-like microglia in vitro and eludes to possible functions and signalling cascades that may evoke this distinct morphology. More investigations are required to fully elucidate the function that rod microglia play in neurological diseases.

Item Type: Article
Authors/Creators:Holloway, OG and Canty, AJ and King, AE and Ziebell, JM
Keywords: Rod microglia, Ageing, Neurological disease, Traumatic brain injury (TBI), Neuroinflammation
Journal or Publication Title: Seminars in Cell and Developmental Biology
Publisher: Academic Press Ltd Elsevier Science Ltd
ISSN: 1084-9521
DOI / ID Number:
Copyright Information:

Copyright 2019 Elsevier Ltd.

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