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Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome

Lucia, D, Burgess, D, Cullen, CL ORCID: 0000-0001-6929-6258, Dorey, ES, Rawashdeh, O and Moritz, KM 2019 , 'Periconceptional maternal alcohol consumption leads to behavioural changes in adult and aged offspring and alters the expression of hippocampal genes associated with learning and memory and regulators of the epigenome' , Behavioural Brain Research, vol. 362 , pp. 249-257 , doi: 10.1016/j.bbr.2019.01.009.

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Abstract

Maternal alcohol consumption throughout pregnancy can result in long term behavioural deficits in offspring. However, less is known about the impact of alcohol during the periconceptional period (PC). The aim of this study was to examine the effect of PC ethanol (PC:EtOH) exposure on long term cognitive function; including memory and anxiety. Rats were exposed to a liquid diet containing ethanol (EtOH) (12.5% vol;vol) or a control diet from 4 days prior to mating until day 4 of pregnancy.Separate cohorts of animals were tested at 6 months (adult) or 15-18 months of age (aged). Offspring underwent a series of behavioural tests to assess anxiety, spatial and recognition memory. The hippocampus was collected, and mRNA expression of epigenetic modifiers and genes implicated in learning and memory were examined. PC:EtOH exposure resulted in a subtle anxiety like behaviour in adult female offspring with a significant reduction in directed exploring/head dipping behaviour during holeboard testing. In aged male offspring, PC:EtOH exposure resulted in a tendency for increased directed exploring/head dipping behaviour during holeboard testing. No differences between treatments were observed in the elevated plus maze. Aged female offspring exposed to PC:EtOH demonstrated short term spatial memory impairment (P dnmt1, dnmt3a and hdac2). In conclusion, PC:EtOH can lead to sex specific anxiety-like behaviour and impairments in spatial memory and altered hippocampal gene expression.

Item Type: Article
Authors/Creators:Lucia, D and Burgess, D and Cullen, CL and Dorey, ES and Rawashdeh, O and Moritz, KM
Keywords: spatial memory, anxiety, hippocampus, methyltransferases, NMDR2A, NMDR2B
Journal or Publication Title: Behavioural Brain Research
Publisher: Elsevier Science Bv
ISSN: 0166-4328
DOI / ID Number: 10.1016/j.bbr.2019.01.009
Copyright Information:

© 2019 Elsevier B.V. All rights reserved.

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