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CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping

Haslbauer, JD, Lindner, S, Valbuena-Lopez, S, Zainal, H, Zhou, H, D'Angelo, T, Pathan, F ORCID: 0000-0002-0939-5470, Arendt, CA, Bug, G, Serve, H, Vogl, TJ, Zeiher, AM, Carr-White, G, Nagel, E and Puntmann, VO 2019 , 'CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping' , International Journal of Cardiology, vol. 275 , pp. 179-186 , doi: 10.1016/j.ijcard.2018.10.023.

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Abstract

Background: Cancer-related treatment is associated with development of heart failure and poor outcome in cancer-survivors. T1 and T2 mapping by cardiovascular magnetic resonance (CMR) may detect myocardial injury due to cancer-related treatment.Methods: Patients receiving cancer-related treatment regimes underwent screening of cardiac involvement with CMR, either within 3 months (early Tx) or >12 months (late Tx) post-treatment. T1 and T2 mapping, cardiac function, strain, ischaemia-testing, scar-imaging and serological cardiac biomarkers were obtained.Results: Compared to age/gender matched controls (n = 57), patients (n = 115, age (yrs): median(IQR) 48(28-60), females, n = 60(52%) had reduced left ventricular ejection fraction (LV-EF) and strain, and higher native T1 and T2. The early Tx group (n = 52) had significantly higher native T1, T2 and troponin levels compared to the late Tx group, indicating myocardial inflammation and oedema (p Conclusions: Native T1 and T2 mapping can be valuable in detecting and monitoring of cardiac involvement with cancer-related treatment, providing distinct biosignatures of early inflammatory involvement (raised native T1 and T2) and interstitial fibrosis and remodelling (raised native T1 but not T2), respectively. Our findings may provide an algorithm allowing to identify susceptible myocardium to potentially guide cardio-protective treatment measures.

Item Type: Article
Authors/Creators:Haslbauer, JD and Lindner, S and Valbuena-Lopez, S and Zainal, H and Zhou, H and D'Angelo, T and Pathan, F and Arendt, CA and Bug, G and Serve, H and Vogl, TJ and Zeiher, AM and Carr-White, G and Nagel, E and Puntmann, VO
Journal or Publication Title: International Journal of Cardiology
Publisher: Elsevier Sci Ireland Ltd
ISSN: 0167-5273
DOI / ID Number: 10.1016/j.ijcard.2018.10.023
Copyright Information:

© 2018 Elsevier B.V. All rights reserved.

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