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Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard

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Andrade, P, Pinho, C, Perez i de Lanuza, G, Afonso, S, Brejcha, J, Rubin, CJ, Wallerman, O, Pereira, P, Sabatino, SJ, Bellati, A, Pellitteri-Rosa, D, Bosakova, Z, Bunikis, I, Carretero, MA, Feiner, N, Marsik, P, Pauperio, F, Salvi, D, Soler, L, While, GM ORCID: 0000-0001-8122-9322, Uller, T, Font, E, Andersson, L and Carneiro, M 2019 , 'Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard' , Proceedings of the National Academy of Sciences , p. 201820320 , doi: 10.1073/pnas.1820320116.

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Abstract

Reptiles show an amazing color diversity based on variation in melanins, carotenoids, and pterins. This study reveals genes controlling differences between three color morphs (white, orange, and yellow) in the common wall lizard. Orange pigmentation, due to high levels of orange/red pterins in skin, is caused by genetic changes in the sepiapterin reductase gene. Yellow skin, showing high levels of yellow carotenoids, is controlled by the beta-carotene oxygenase 2 locus. Thus, the color polymorphism in the common wall lizard is associated with changes in two small regions of the genome containing genes with crucial roles in pterin and carotenoid metabolism. These genes are likely to have pleiotropic effects on behavior and other traits associated with the different color morphs.

Item Type: Article
Authors/Creators:Andrade, P and Pinho, C and Perez i de Lanuza, G and Afonso, S and Brejcha, J and Rubin, CJ and Wallerman, O and Pereira, P and Sabatino, SJ and Bellati, A and Pellitteri-Rosa, D and Bosakova, Z and Bunikis, I and Carretero, MA and Feiner, N and Marsik, P and Pauperio, F and Salvi, D and Soler, L and While, GM and Uller, T and Font, E and Andersson, L and Carneiro, M
Keywords: Podarcis muralis, carotenoid pigmentation, pterin pigmentation, balanced polymorphism, introgression
Journal or Publication Title: Proceedings of the National Academy of Sciences
Publisher: Natl Acad Sciences
ISSN: 0027-8424
DOI / ID Number: 10.1073/pnas.1820320116
Copyright Information:

Copyright 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

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