Open Access Repository

Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia

Palmer, AJ ORCID: 0000-0002-9703-7891, van der Mei, I ORCID: 0000-0001-9009-7472, Taylor, BV, Clarke, PM, Simpson Jr, S ORCID: 0000-0001-6521-3056 and Ahmad, H ORCID: 0000-0002-2580-9856 2019 , 'Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia' , Multiple Sclerosis Journal , pp. 1-10 , doi: 10.1177/1352458519831213.

Full text not available from this repository.

Abstract

Objectives: To quantify life expectancy (LE), quality-adjusted life years (QALYs) and total lifetime societal costs for a hypothetical cohort of Australians with multiple sclerosis (MS).Methods: A 4-state Markov model simulated progression from no/mild to moderate and severe disability and death for a cohort of 35-year-old women over a lifetime horizon. Death risks were calculated from Australian life tables, adjusted by disability severity. State-dependent relapse probabilities and associated disutilities were considered. Probabilities of MS progression and relapse were estimated from AusLong and TasMSL MS epidemiological databases. Annual societal (direct and indirect) costs (2017 Australian dollars) and health-state utilities for each state were derived from the Australian MS Longitudinal Study. Costs were discounted at 5% annually.Results: Mean (95% confidence interval (CI)) LE from age 35 years was 42.7 (41.6-43.8) years. This was 7.5 years less than the general Australian population. Undiscounted QALYs were 28.2 (26.3-30.0), a loss of 13.1 QALYs versus the Australian population. Discounted lifetime costs were $942,754 ($347,856-$2,820,219).Conclusion: We have developed a health economics model of the progression of MS, calculating the impact of MS on LE, QALYs and lifetime costs in Australia. It will form the basis for future cost-effectiveness analyses of interventions for MS.

Item Type: Article
Authors/Creators:Palmer, AJ and van der Mei, I and Taylor, BV and Clarke, PM and Simpson Jr, S and Ahmad, H
Keywords: Australia, Markov model, multiple sclerosis, QALYs, life expectancy, lifetime costs
Journal or Publication Title: Multiple Sclerosis Journal
Publisher: Arnold
ISSN: 1352-4585
DOI / ID Number: 10.1177/1352458519831213
Copyright Information:

Copyright 2019 The Authors

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP