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Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity

Crunelli, V, Lorincz, ML, Connelly, WM ORCID: 0000-0002-0986-6260, David, F, Hughes, SW, Lambert, RC, Leresche, N and Errington, AC 2018 , 'Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity' , Nature reviews. Neuroscience, vol. 19, no. 2 , pp. 107-118 , doi: 10.1038/nrn.2017.151.

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Abstract

During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a range of frequencies from 2+ spikes. Recent evidence reveals that thalamic Ca2+ spikes are inextricably linked to global somatodendritic Ca2+ transients and are essential for several forms of thalamic plasticity. Thus, we propose herein that alongside their rhythm-regulation function, thalamic oscillations of low-vigilance states have a plasticity function that, through modifications of synaptic strength and cellular excitability in local neuronal assemblies, can shape ongoing oscillations during inattention and NREM sleep and may potentially reconfigure thalamic networks for faithful information processing during attentive wakefulness.

Item Type: Article
Authors/Creators:Crunelli, V and Lorincz, ML and Connelly, WM and David, F and Hughes, SW and Lambert, RC and Leresche, N and Errington, AC
Keywords: Sleep, Epilepsy, Oscillations, Plasticity, Thalamus
Journal or Publication Title: Nature reviews. Neuroscience
Publisher: Nature Pub. Group
ISSN: 1471-003X
DOI / ID Number: 10.1038/nrn.2017.151
Copyright Information:

Copyright 2017 Macmillan Publishers Limited, part of Springer Nature

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