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The metabolomic signatures of alcohol consumption in young adults

Du, DH ORCID: 0000-0002-9181-3386, Bruno, R ORCID: 0000-0001-6673-833X, Blizzard, L ORCID: 0000-0002-9541-6943, Venn, A ORCID: 0000-0001-7090-1398, Dwyer, T, Smith, KJ ORCID: 0000-0003-2793-3460, Magnussen, CG ORCID: 0000-0002-6238-5730 and Gall, S ORCID: 0000-0002-5138-2526 2019 , 'The metabolomic signatures of alcohol consumption in young adults' , European Journal of Preventive Cardiology, no. March , pp. 1-10 , doi: 10.1177/2047487319834767.

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Background:Metabolomic analysis may help us to understand the association between alcohol consumption and cardio-metabolic health. We aimed to: (i) replicate a previous study of alcohol consumption and metabolic profiles, (ii) examine associations between types of alcoholic beverages and metabolites and (iii) include potential confounders not examined in previous studies.Methods:Cross-sectional data of 1785 participants (age 26-36 years, 52% women) from the 2004-2006 Childhood Determinants of Adult Health study were used. Consumption of beer, wine and spirits was assessed by questionnaires. Metabolites were measured by a high-throughput nuclear magnetic resonance platform and multivariable linear regression examined their association with alcohol consumption (combined total and types) adjusted for covariates including socio-demographics, health behaviours and mental health.Results:Alcohol consumption was associated with 23 out of 37 lipids, 12 out of 16 fatty acids and six out of 20 low-molecular-weight metabolites independent of confounders with similar associations for combined total alcohol consumption and different types of alcohol. Many metabolites (lipoprotein lipids in high-density lipoprotein (HDL) subclasses, HDL cholesterol, apolipoprotein A-1, phosphotriglycerides, total fatty acids, monounsaturated fatty acids, omega-3 fatty acids) had positive linear associations with alcohol consumption but some showed negative linear (low-density lipoprotein particle size, omega-6 fatty acids ratio to total fatty acids, citrate) or U-shaped (lipoprotein lipids in very-low-density lipoprotein (VLDL) subclasses, VLDL triglycerides) associations.Conclusions:Our results were similar to those of the only previous study. Associations with metabolites were similar for total and types of alcohol. Alcohol consumption in young adults is related to a diverse range of metabolomic signatures associated with benefits and harms to health.

Item Type: Article
Authors/Creators:Du, DH and Bruno, R and Blizzard, L and Venn, A and Dwyer, T and Smith, KJ and Magnussen, CG and Gall, S
Keywords: alcohol, epidemiology, risk factors, metabolomics, fatty acids, metabolic profiling, cardiometabolic health
Journal or Publication Title: European Journal of Preventive Cardiology
Publisher: Sage Publications Ltd.
ISSN: 2047-4873
DOI / ID Number: 10.1177/2047487319834767
Copyright Information:

Copyright 2019 The European Society of Cardiology

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