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The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer’s disease

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Pietzuch, M, King, AE ORCID: 0000-0003-1792-0965, Ward, DD and Vickers, JC ORCID: 0000-0001-5671-4879 2019 , 'The influence of genetic factors and cognitive reserve on structural and functional resting-state brain networks in aging and Alzheimer’s disease' , Frontiers in Aging Neuroscience, vol. 11 , pp. 1-14 , doi: 10.3389/fnagi.2019.00030.

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Abstract

Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met.

Item Type: Article
Authors/Creators:Pietzuch, M and King, AE and Ward, DD and Vickers, JC
Keywords: fMRI, Alzheimer's disease, default mode network, cognitive reserve, BDNF, APOE, dementia, genetics, ageing
Journal or Publication Title: Frontiers in Aging Neuroscience
Publisher: Frontiers Research Foundation
ISSN: 1663-4365
DOI / ID Number: 10.3389/fnagi.2019.00030
Copyright Information:

Copyright 2019 Pietzuch, King, Ward and Vickers. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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