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Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: A pilot study

Zhao, B ORCID: 0000-0001-5423-971X, Johnston, FH ORCID: 0000-0002-5150-8678, Dalton, M and Negishi, K ORCID: 0000-0002-9086-2565 2019 , 'Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: A pilot study' , Pediatric Cardiology , pp. 1-7 , doi: 10.1007/s00246-019-02088-1.

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Introduction: In adults, noninvasive assessments of vascular function have been established. However, little is known about the applicability and reference values of these techniques among children Methods: Carotid intima-media thickness (cIMT) and abdominal aorta IMT (aaIMT), pulse wave velocity (PWV), arterial diameter change, stiffness index (β), and distensibility were assessed in 2-year-old children. IMT was assessed using an automatic contour detection.Results: The proportion of successful measurements was 72% (42/58) with cIMT 64%, aaIMT 67%, and PWV 43%. Average far wall cIMT was 0.51 mm and 0.40 for aaIMT. Mean PWV was 4.15 m/s, with relatively wider range in stiffness index and distensibility. Common carotid arteries had a higher mean distensibility of 4.58%/10 mmHg compared with 2.98%/10 mmHg for the abdominal aorta. The number of data points automatically detected at far wall cIMT was higher than that in aaIMT (left cIMT: 244 ± 13 and right: 240 ± 23 vs. abdominal 185 ± 63, p Conclusions: Noninvasive methods for early detection of cardiovascular risks were feasible in at least two-thirds of 2-year-old children. Given the greater feasibility and image quality, cIMT is a preferable option for assessing vascular health in young children.

Item Type: Article
Authors/Creators:Zhao, B and Johnston, FH and Dalton, M and Negishi, K
Keywords: arterial stiffness, children, intima-media thickness, pulse wave velocity
Journal or Publication Title: Pediatric Cardiology
Publisher: Springer-Verlag
ISSN: 0172-0643
DOI / ID Number: 10.1007/s00246-019-02088-1
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Copyright 2019 Springer Science+Business Media, LLC, part of Springer Nature

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