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Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice

Collins, JM ORCID: 0000-0002-1938-2470, King, AE ORCID: 0000-0003-1792-0965, Woodhouse, A ORCID: 0000-0002-4246-7624, Kirkcaldie, MTK ORCID: 0000-0003-3285-0168 and Vickers, JC ORCID: 0000-0001-5671-4879 2019 , 'Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice' , Journal of Neurotrauma, vol. 36, no. 11 , pp. 1876-1889 , doi: 10.1089/neu.2018.5982.

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Abstract

Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to ageing and the onset of AD pathology is not known. In this study, we have examined the effect of TBI on subsequent beta-amyloid (Aβ) deposition in APP/PS1 (APPSWE/PSEN1dE9) transgenic mice either before (3 months of age) or after the onset (6 months of age) of plaque pathology. Lateral fluid percussion (LFPI), a model of diffuse brain injury, was induced in APP/PS1 and C57Bl/6 wild-type littermates (WT). LFPI caused a significant increase in both total (pppp>0.05), Aβ plaque load compared to sham treated mice. No Aβ plaques were present in any WT mice across these conditions. GFAP-immunolabelling of astrocytes and Iba-1-immunolabelling of microglial/macrophages was not significantly different (pβ plaque deposition depending on age and the stage of amyloidosis at the time of injury.

Item Type: Article
Authors/Creators:Collins, JM and King, AE and Woodhouse, A and Kirkcaldie, MTK and Vickers, JC
Keywords: Alzheimer's disease, beta-amyloid, brain Injury; APP/PS1dementia, traumatic brain Injury
Journal or Publication Title: Journal of Neurotrauma
Publisher: Mary Ann Liebert Inc Publ
ISSN: 0897-7151
DOI / ID Number: 10.1089/neu.2018.5982
Copyright Information:

Copyright 2019 Mary Ann Liebert, Inc.

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