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The emerging role of voltage-gated sodium channels in tumor biology

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Mao, W, Zhang, J, Korner, H ORCID: 0000-0003-4610-2814, Jiang, Y and Ying, S 2019 , 'The emerging role of voltage-gated sodium channels in tumor biology' , Frontiers in Oncology, vol. 9, no. March , pp. 1-8 , doi: 10.3389/fonc.2019.00124.

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Abstract

Voltage-gated sodium channels (VGSCs) are transmembrane proteins which function as gates that control the flux of ions across the cell membrane. They are key ion channels for action potentials in excitable tissues and have important physiological functions. Abnormal function of VGSCs will lead to dysfunction of the body and trigger a variety of diseases. Various studies have demonstrated the participation of VGSCs in the progression of different tumors, such as prostate cancer, cervical cancer, breast cancer, and others, linking VGSC to the invasive capacity of tumor cells. However, it is still unclear whether the VGSC regulate the malignant biological behavior of tumors. Therefore, this paper systematically addresses the latest research progress on VGSCs subunits and tumors and the underlying mechanisms, and it summarizes the potential of VGSCs subunits to serve as potential targets for tumor diagnosis and treatment.

Item Type: Article
Authors/Creators:Mao, W and Zhang, J and Korner, H and Jiang, Y and Ying, S
Keywords: VGSCs, expression regulation, mechanism, metastasis, tumors
Journal or Publication Title: Frontiers in Oncology
Publisher: Frontiers Research Foundation
ISSN: 2234-943X
DOI / ID Number: 10.3389/fonc.2019.00124
Copyright Information:

Copyright 2019 Mao, Zhang, Korner, Jiang and Ying. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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