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APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Czeczor, JK, Genders, AJ, Aston-Mourney, K, Connor, T, Hall, LG, Hasebe, K, Ellis, M, De Jong, KA, Henstridge, DC ORCID: 0000-0003-4988-767X, Meikle, PJ, Febbraio, MA, Walder, K and McGee, SL 2018 , 'APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding' , Journal of Endocrinology, vol. 237, no. 3 , pp. 311-322 , doi: 10.1530/JOE-18-0051.

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Abstract

The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide that is implicated in the development of Alzheimer’s disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism. Compared with WT littermates, APP-deficient mice were resistant to diet-induced obesity, which was linked to higher energy expenditure and lipid oxidation throughout the dark phase and was associated with increased spontaneous physical activity. Consistent with this lean phenotype, APP-deficient mice fed a high-fat diet (HFD) had normal insulin tolerance. However, despite normal insulin action, these mice were glucose intolerant, similar to WT mice fed a HFD. This was associated with reduced plasma insulin in the early phase of the glucose tolerance test. Analysis of the pancreas showed that APP was required to maintain normal islet and β-cell mass under high fat feeding conditions. These studies show that, in addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.

Item Type: Article
Authors/Creators:Czeczor, JK and Genders, AJ and Aston-Mourney, K and Connor, T and Hall, LG and Hasebe, K and Ellis, M and De Jong, KA and Henstridge, DC and Meikle, PJ and Febbraio, MA and Walder, K and McGee, SL
Keywords: amyloid precursor protein, energy expenditure glucose metabolism, insulin secretion, obesity, amyloid precursor protein, cyclic AMP dependent protein kinase, cyclic AMP responsive element binding protein, genomic DNA, glucose, insulin, lipid, male
Journal or Publication Title: Journal of Endocrinology
Publisher: BioScientifica Ltd.
ISSN: 0022-0795
DOI / ID Number: 10.1530/JOE-18-0051
Copyright Information:

Copyright 2018 Society for Endocrinology

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