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Cannabinoid interventions for PTSD: Where to next?

Ney, LJ, Matthews, AJ ORCID: 0000-0003-2961-9125, Bruno, R ORCID: 0000-0001-6673-833X and Felmingham, KL 2019 , 'Cannabinoid interventions for PTSD: Where to next?' , Progress in Neuropsychopharmacology and Biological Psychiatry, vol. 93 , pp. 124-140 , doi: 10.1016/j.pnpbp.2019.03.017.

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Abstract

Cannabinoids are a promising method for pharmacological treatment of post-traumatic stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid modulation on PTSD symptomology, there is not a currently agreed way by which the cannabinoid system should be targeted in humans. In this review, we present an overview of recent research identifying neurological pathways by which different cannabinoid-based treatments may exert their effects on PTSD symptomology. We evaluate the strengths and weaknesses of each of these different approaches, including recent challenges presented to favourable options such as fatty acid amide hydrolase (FAAH) inhibitors. This article makes the strengths and challenges of different potential cannabinoid treatments accessible to psychological researchers interested in cannabinoid therapeutics and aims to aid selection of appropriate tools for future clinical trials.

Item Type: Article
Authors/Creators:Ney, LJ and Matthews, AJ and Bruno, R and Felmingham, KL
Keywords: endocannabinoids, posttraumatic stress disorder, translational medical research, cannabis, sychiatric disorders, traumatic stress, cannabinoids,PTSD
Journal or Publication Title: Progress in Neuropsychopharmacology and Biological Psychiatry
Publisher: Elsevier
ISSN: 0278-5846
DOI / ID Number: 10.1016/j.pnpbp.2019.03.017
Copyright Information:

Copyright 2019 Elsevier Inc.

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