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Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS


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Simpson Jr, S ORCID: 0000-0001-6521-3056, Taylor, KL, Jelinek, GA, De Livera, AM, Brown, CR, O'Kearney, E, Neate, SL, Bevens, W and Weiland, TJ 2019 , 'Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS' , Multiple Sclerosis and Related Disorders, vol. 30 , pp. 165-175 , doi: 10.1016/j.msard.2019.02.014.

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Background: Depression is highly prevalent among people with MS, and determinants thereof would be useful.Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS.Methods: Positive depression-screen assessed by Patient Health Questionnaire (PHQ)-2 and PHQ-9. Associations of demographic and clinical factors with depression-screen and change thereof assessed using multivariable regression models, adjusted for age, sex, disability, fatigue, antidepressant use, and baseline PHQ-2, as appropriate.Results: Overweight/obese BMI, comorbidity number, fatigue, and disability were associated with positive depression-screen, while married/partnered state, being employed, higher perceived socioeconomic status, and greater education were inversely associated with depression-screen. After adjustment, only marital status, socioeconomic status, antidepressant medication use, and fatigue were associated with risk of newly positive depression-screen. MS type, relapse number and immunomodulatory medication use were not associated with depression-screen after controlling for disability and fatigue.Conclusion: In a large prospective cohort study of depression in people with MS, we substantiated several potential determinants of a positive depression-screen and depression trajectory, particularly fatigue. Given that fatigue is the most common and most significant clinical symptom for people with MS, efforts to reduce fatigue may have follow-on benefits for reducing depression.

Item Type: Article
Authors/Creators:Simpson Jr, S and Taylor, KL and Jelinek, GA and De Livera, AM and Brown, CR and O'Kearney, E and Neate, SL and Bevens, W and Weiland, TJ
Keywords: clinical, demographic, depression, epidemiology, multiple sclerosis
Journal or Publication Title: Multiple Sclerosis and Related Disorders
Publisher: Elsevier BV
ISSN: 2211-0348
DOI / ID Number: 10.1016/j.msard.2019.02.014
Copyright Information:

Copyright 2019 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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