Open Access Repository

Tail loss and telomeres: consequences of large-scale tissue regeneration in a terrestrial ectotherm

Fitzpatrick, LJ, Olsson, M, Parsley, LM ORCID: 0000-0003-1225-5484, Pauliny, A, While, GM ORCID: 0000-0001-8122-9322 and Wapstra, E ORCID: 0000-0002-2050-8026 2019 , 'Tail loss and telomeres: consequences of large-scale tissue regeneration in a terrestrial ectotherm' , Biology Letters, vol. 15, no. 7 , pp. 1-5 , doi: 10.1098/rsbl.2019.0151.

Full text not available from this repository.

Abstract

Large-scale tissue regeneration has potential consequences for telomere length through increases in cell division and changes in metabolism which increase the potential for oxidative stress damage to telomeres. The effects of regeneration on telomere dynamics have been studied in fish and marine invertebrates, but the literature is scarce for terrestrial species. We experimentally induced tail autotomy in a lizard (Niveoscincus ocellatus) and assessed relative telomere length (RTL) in blood samples before and after partial tail regeneration while concurrently measuring reactive oxygen species (ROS) levels. The change in ROS levels was a significant explanatory variable for the change in RTL over the 60-day experiment. At the average value of ROS change, the mean RTL increased significantly in the control group (intact tails), but there was no such evidence in the regenerating group. By contrast, ROS levels decreased significantly in the regenerating group, but there was no such evidence in the control group. Combined, these results suggest that tail regeneration following autotomy involves a response to oxidative stress and this potentially comes at a cost to telomere repair. This change in telomere maintenance demonstrates a potential long-term cost of tail regeneration beyond the regrowth of tissue itself.

Item Type: Article
Authors/Creators:Fitzpatrick, LJ and Olsson, M and Parsley, LM and Pauliny, A and While, GM and Wapstra, E
Keywords: oxidative stress, telomere dynamics, tissue regeneration, autotomy, reptile, ectotherm
Journal or Publication Title: Biology Letters
Publisher: The Royal Society Publishing
ISSN: 1744-9561
DOI / ID Number: 10.1098/rsbl.2019.0151
Copyright Information:

Copyright 2019 The Author(s) Published by the Royal Society. All rights reserved.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP